You MUST use "YouTube Ad Skipper" in conjunction with this to get the desired result. Works great for Firefox, okay in Edge, and of course you cannot use it in Chrome because useless Google bought YouTube. Google is now the bloated Microsoft Antichrist of the new millennium.
!@#$ Google everyday of our lives.

It blocks google results by domain, but even when a domain is blocked, all results still appear in google images. Which is ultra annoying. Adblock needs to block ALL results from a domain, images, news, videos, etc.

Works to block the ads and annotations. But now Youtube has a new thing where they force you watch a clicked video after you back out of the page. The said video will continue on your screen as a pop-up window on the bottom right corner. Pretty sneaky and a cheap shot to increase views for the Youtubers. Adblock does nothing for this....I guess it's not an ad so...

Now Youtube has a drop down portion of the screen too. Does nothing for that either. Youtube is unstoppable!

6/16:
The playing video's in the pop-up windows are back. If you view a video that was just click bait and back out of that page the video follows you. This does nothing for it.